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CLA und Körperfett - Nicolai Worm - 09.05.2007

Heute ist eine Metaanalyse erschienen, die zum Ergebnis hat, dass die Zufuhr von 3,2 g CLA/Tag einen geringfügigen Verlust von Körperfett (0,05 Kg/Woche) bewirkt und dass dieser Effekt mit der Zeit noch schwächer wird.

Whigham LD, Watras AC, and Schoeller DA. Efficacy of conjugated
linoleic acid for reducing fat mass: a meta-analysis in humans.
Am J Clin Nutr 2007;85:1203–11.

Background: Conjugated linoleic acid (CLA) has been shown to be
an effective supplement for reducing fat mass in animals, whereas
results in humans have been inconsistent.

Objective: This is a meta-analysis of human studies in which CLA
was provided as a dietary supplement to test its efficacy in reducing
fat mass.

Design: We searched the PubMed database (National Library of
Medicine, Bethesda,MD)and references from the resulting search to
identify studies in which CLA was provided to humans in randomized,
double-blinded, placebo-controlled trials and in which body
composition was assessed by using a validated technique.

Results: We identified 18 eligible studies. Of these, 3 were singleisomer
studies, and results comparing CLA isomers were inconclusive.
We compared the length of treatment by using studies in which
a mixture of purified isomers were used and those in which purified
trans-10,cis-12 isomers were used. This comparison indicated that
the effect of CLA was linear for up to 6 mo and then slowly approached
an asymptote at 2 y.Ananalysis of the dose effect indicated
that fat loss compared with placebo was 0.024 kg·gCLA 1·wk 1
(P<0.03). After adjustment to the median dose of 3.2 g CLA/d,
CLA was effective and produced a reduction in fat mass for the CLA
group alone (0.05 +/-0.05 kg/wk; P<0.001) and for the CLA group
compared with placebo (0.09 0.08 kg/wk; P 0.001)

Conclusion: Given at a dose of 3.2 g/d, CLA produces a modest loss
in body fat in humans.